ABSTRACT
RATIONALE: Shared symptoms and genetic architecture between COVID-19 and lung fibrosis suggests SARS-CoV-2 infection may lead to progressive lung damage. OBJECTIVES: The UKILD Post-COVID study interim analysis was planned to estimate the prevalence of residual lung abnormalities in people hospitalized with COVID-19 based on risk strata. METHODS: The Post-HOSPitalisation COVID Study (PHOSP-COVID) was used for capture of routine and research follow-up within 240 days from discharge. Thoracic CTs linked by PHOSP-COVID identifiers were scored for percentage of residual lung abnormalities (ground glass opacities and reticulations). Risk factors in linked CT were estimated with Bayesian binomial regression and risk strata were generated. Numbers within strata were used to estimate post-hospitalization prevalence using Bayesian binomial distributions. Sensitivity analysis was restricted to participants with protocol driven research follow-up. MEASUREMENTS AND MAIN RESULTS: The interim cohort comprised 3700 people. Of 209 subjects with linked CTs (median 119 days, interquartile range 83-155), 166 people (79.4%) had >10% involvement of residual lung abnormalities. Risk factors included abnormal chest X-ray (RR 1·21 95%CrI 1·05; 1·40), percent predicted DLco<80% (RR 1·25 95%CrI 1·00; 1·56) and severe admission requiring ventilation support (RR 1·27 95%CrI 1·07; 1·55). In the remaining 3491 people, moderate to very-high risk of residual lung abnormalities was classified in 7·8%, post-hospitalization prevalence was estimated at 8.5% (95%CrI 7.6%; 9.5%) rising to 11.7% (95%CrI 10.3%; 13.1%) in sensitivity analysis. CONCLUSIONS: Residual lung abnormalities were estimated in up to 11% of people discharged following COVID-19 related hospitalization. Health services should monitor at-risk individuals to elucidate long-term functional implications. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
ABSTRACT
When schools in Arkansas and most of the country shut their physical doors and moved to remote instruction in March 2020, Rachel Evans, Christian Goering, and Seth French planned to engage in a multifaceted experience that bridged personal narrative writing, songwriting, and podcasting. Undaunted by the shutdown, they offered Evans' ninth-grade students the opportunity to engage asynchronously in what Evans named The Podcast of Our Lives, a project with three distinct goals: (1) use music to connect to their lived experiences;(2) build from that music as a springboard to write a new original song;and (3) develop a reflective podcast about the songwriting and overall process. Given the traumatic impact of COVID-19 on the well-being of students and teachers across the country, there is an urgent need to design and implement lessons that center student emotions, feelings, thoughts, and voices. Evans' students shifted ideas from one form to another, creating a multimodal podcast while revealing their deep emotions as humans in the middle of a global pandemic. Evans, Goering, and French present the article with the end in mind, providing an example podcast, three stages they used with students, and their reflections and ideas for next steps.